Dietary restriction: a mechanism behind its lifespan extension effect

Vermeij et al. show that dietary restriction delays aging and extends lifespan in two mouse models of progeroid human aging, by alleviating DNA damage.

Progeroid syndromes are relatively rare genetic disorders that show premature aging-like symptoms, for example Werner’s syndrome, Cockayne syndrome, and Hutchinson-Gilford progeria syndrome.

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

Nature 537 (427–431), 15 September 2016

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